Accumulated phosphatidylcholine (16:0/16:1) in human colorectal cancer; possible involvement of LPCAT4.
作者： Nobuya Kurabe , Takahiro Hayasaka , Mikako Ogawa , Noritaka Masaki , Yoshimi Ide
DOI: 10.1111/CAS.12221
关键词:
摘要: The identification of cancer biomarkers is critical for target-linked therapy. overall level phosphatidylcholine (PC) elevated in colorectal (CRC). To investigate which species PC overexpressed cancer, an imaging mass spectrometry was performed using a panel non-neoplastic mucosal and CRC tissues. In the present study, we identified novel biomarker, PC(16:0/16:1), spectrometry. Specifically, levels PC(16:0/16:1) expression were observed more advanced stage CRC. Our data further showed that specifically localized region when examined Notably, because ratio to lyso-PC(16:0) higher CRC, postulated lyso-PC acyltransferase (LPCAT) activity vitro analysis, LPCAT4 involved deregulation immunohistochemical shown be These indicate potential usefulness clinical diagnosis implicate
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