A menstruation-linked periodic hypersomnia: Kleine‐Levin syndrome or new clinical entity?

摘要: A 13-year-old girl showed periodic episodes of somnolence without megaphagia recurring in association with each menstruation. During somnolent total sleep time averaged 14 hours and 19 minutes per 24 hours. The level performance evaluated by means the Wilkinson Addition Test was significantly impaired. There an abnormal increase 5-hydroxyindolacetic acid cerebrospinal fluid after probenecid test, suggesting turnover 5-hydroxytryptamine during hypersomnia. Investigation menstrual cycle failed to document any striking hormonal abnormality. Nevertheless, close relationship between hypersomnia end led us hypothesize a role progesterone try type treatment that is thus far successful.