Clinical Potentials of Adsorptive Dialysis Membrane: A Toray Symposium - EDTA, Paris, May 2012

摘要: and proteins to a surface, but without actually penetrating the surface. This process depends mostly upon internal pore structure hydrophobic properties of dialysis membrane. So far, potential survival benefit adsorption has not been examined. There is, however, growing body evidence suggesting improvement on removal AGEs, homocysteine erythropoiesis inhibitors or increased response vaccination [3, 4] . In this supplemental issue Blood Purification , several reviews discuss clinical benefits membranes with high adsorptive properties. Renal insufficiency is frequent complication multiple myeloma which may affect up 50% patients, 15–20% them developing acute renal failure 10% these patients later becoming dependent. A substantial proportion develop distinct form (cast nephropathy) due concentrations monoclonal free light chains (FLC) in plasma hence urine, leading precipitation aggregation uromodulin tubular casts. early circulating FLC paramount importance recover normal function. conjunction bortezomib-based chemotherapy, extracorporeal be achieved exchanges more recently by haemodialysis using high-permeability filters very cutoff (HCO), close 55 kDa, thus potentially capable reHaemodialysis for chronic encompasses 3 different biophysical processes, namely dialysis, convection adsorption. The relative part each varies largely according chemical membranes, electrostatic charges Dialysis small molecules along concentration gradient cornerstone therapy during last decades. However, an index solute clearance, HEMO study failed show mortality when equilibrated KT/V urea was from 1.05 1.45 per session, that most diffusive are obtained classic 4to 5-hour session [1] Larger (middle-molecular-weight uraemic toxins) protein-bound can cleared haemodiafiltration, i.e. large volume generally >20 litres session. CONTRAST examined associated haemodiafiltration versus standard conventional low-flux dialysis. trial any treatment despite achieving significant intermediate end points (β2-microglobulin, etc.) [2] Adsorption accumulation adhesion molecules, ions larger particles including macromolecules Published online: