Assessing apparent treatment—covariate interactions in randomized clinical trials
作者： David P. Byar
关键词:
摘要: Abstract In the context of clinical trials, a qualitative treatment--covariate interaction occurs when patient's preferred treatment depends on his covariates. this paper I review nature and interpretation various kinds interactions, compare use overall tests for to subset analysis, present some examples apparent treatment-covariate interactions that have arisen in actual randomized discuss recent work by others related significance testing, estimation assessment interactions.
sci-hub.se 参考文章(6)
David P. Byar, Donald K. Corle, Selecting optimal treatment in clinical trials using covariate information Journal of Chronic Diseases. ,vol. 30, pp. 445- 459 ,(1977) , 10.1016/0021-9681(77)90037-6
Paul L. Canner, Further aspects of data analysis Controlled Clinical Trials. ,vol. 4, pp. 485- 503 ,(1983) , 10.1016/0197-2456(83)90030-2
Thomas A. Louis, Estimating a population of parameter values using Bayes and empirical Bayes methods Journal of the American Statistical Association. ,vol. 79, pp. 393- 398 ,(1984) , 10.1080/01621459.1984.10478062
Jonathan Shuster, Jan van Eys, Interaction between prognostic factors and treatment Controlled Clinical Trials. ,vol. 4, pp. 209- 214 ,(1983) , 10.1016/S0197-2456(83)80026-9
D P Byar, S B Green, The choice of treatment for cancer patients based on covariate information. Bulletin Du Cancer. ,vol. 67, pp. 477- 490 ,(1980)
Frederick Mosteller, Lawrence A Thibodeau, Joseph A Ingelfinger, Biostatistics in clinical medicine Published in <b>1983</b> in New York NY) by Macmillan. ,(1983)