Modeling Cytomegalovirus Infection in Mouse Tumor Models

摘要: The hypothesis that cytomegalovirus (CMV) modulates cancer is evolving. Originally discovered in glioblastoma 2002, the number of cancers, where intratumoral antigen detected, has increased recent years suggesting CMV actively affect pathobiology certain tumors. These findings are controversial as several groups have also reported inability to replicate these results. Regardless, clinical trials for underway or been completed target with anti-viral drugs immunotherapy. Therefore, a better understanding possible needs be ascertained. We developed genetic, syngeneic, and orthotopic malignant glioma mouse models study role development progression. recapitulate most part expression seen human Additionally, we infection Trp53-/+ mice promotes pleomorphic rhabdomyosarcomas. not only vehicle studying viral-tumor interaction, but platform developing testing therapeutics.