Effect of acute muscle contusion injury, with and without dietary fish oil, on adult and aged male rats: contractile and biochemical responses

摘要: Abstract Aim Contusion injury in aging muscle has not been studied detail, but older adults are at risk for such injuries due to increased of falls. As falls populations unlikely be eliminated, interventions minimize the negative impact falls, including contusion should pursued. Dietary fish oil (FO) is a common often supplement adults, which associated with factors that might reduce or worsen contusion. Methods Here, we investigate whether 8 weeks FO can blunt adult (n = 14) and aged (n = 12) rats. We assessed contractility several biochemical markers gastrocnemius muscles 48 h post-contusion injury, using uninjured as controls. Results Injury reduced force production ~40% (P  Conclusion Although age-related differences certain protein differed, exhibited no greater acute functional deficits following injury. Similarly, while did deficits, it them. However, changes Myf5 DRP1 dietary suggest potential improve recovery from investigated future studies.