Muscle-specificity of age-related changes in markers of autophagy and sphingolipid metabolism.
作者： David W. Russ , Iva M. Boyd , Katherine M. McCoy , Katherine W. McCorkle
DOI: 10.1007/S10522-015-9598-4
关键词:
摘要: Our previous findings indicate that the gastrocnemius muscle of aging rats exhibits impairments quality (force/unit tissue) and autophagy increased sarcoplasmic reticulum stress. The purpose this study was to examine age-related changes in soleus contractility markers muscles. We assessed situ force size adult (7-8 months) aged (24-26 male, F344/BN rats. used immunoblotting compare abundance autophagy, (SR) stress sphingolipid metabolism medial (MG) muscles these animals. Relative adults, maintained size, resulting tetanic production. Immunoblotting revealed a general pattern an reduction basal despite increases indicators SR upstream autophagic pathway activation MG. MG also exhibited suggestive ceramide. Minimal were observed soleus. maintains mass with age, fewer than Based on data, we suggest maintenance may preserve by preventing excessive
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