Direct-acting mutagenic activity in white, rosé, and red wines with the Ara test of Salmonella typhimurium.
作者： Rafael R. Ariza , Angeles Serrano , Carmen Pueyo
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摘要: Thirty-two commercially produced white, rose, and red wines from Spain were assayed for genotoxicity. The Ara forward mutagenicity assay with Salmonella typhimurium served as the test system. All mutagenic in absence of mammalian microsomal activation (S9 mix) and/or glycosidase activities exception one rose wine which gave a clear dose-response relationship, although its potency was considered statistically nonsignificant. activity covered nearly 30-fold range. Compared to white wines, showed highest levels mutagenicity; this type included four "very potent" (greater than 3,000 AraR mutants/ml) wines. level did not correlate either region or year production (vintage). Individual winery methods are suggested primarily responsible variations activity. present study supports possibility that components other flavonols quercetin rutin major putative mutagens: (1) well detected being mutagenic; (2) no case required detection (3) mutagen(s) mainly (red wine) when exclusively (white polar fraction XAD-2 chromatography. high sensitivity has allowed screening variety previous process extraction concentration. comparison entire complex mixture lyophilized residue revealed positive synergistic role ethanol certain Finally, work suggests is useful tool Thus, might play an important elucidating genotoxic mechanism action alcoholic beverages, studying optional decrease commercial
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