Mean platelet volume is associated with infarct size and microvascular obstruction estimated by cardiac magnetic resonance in ST segment elevation myocardial infarction

摘要: Mean platelet volume (MPV) is an indicator of activation. High MPV has been recently considered as independent risk factor for poor outcomes after ST-segment elevation myocardial infarction (STEMI). We analyzed 128 patients diagnosed with first STEMI successfully reperfused during three consecutive years. was measured on admission and a cardiac magnetic resonance (CMR) exam performed within the week in all patients. Myocardial necrosis size estimated by area late gadolinium enhancement (LGE), identifying microvascular obstruction (MVO), if present. Clinical were recorded at 1 year follow-up. defined value third tertile (≥9.5 fl), low MPV, lower two. found slight but significant correlation between infarct (r = 0.287, P 0.008). Patients high had more extensive infarcted (percentage LGE: 17.6 vs. 12.5%, 0.021) presence MVO (patients pattern: 44.4 25.3%, 0.027). In multivariable analysis, hazard ratio major adverse events 3.35 [95% confidence interval (CI) 1.1-9.9, 0.03] MPV. associated higher CMR.