Zuo1 supports G4 structure formation and directs repair toward nucleotide excision repair.

摘要: Nucleic acids can fold into G-quadruplex (G4) structures that fine-tune biological processes. Proteins are required to recognize G4 and coordinate their function. Here we identify Zuo1 as a novel G4-binding protein in vitro vivo. In vivo the absence of fewer form, cell growth slows cells become UV sensitive. Subsequent experiments reveal these cellular changes due reduced levels structures. function at results recruitment nucleotide excision repair (NER) factors, which has positive effect on genome stability. Cells lacking functional NER, well Zuo1, accumulate structures, accessible translesion synthesis. Our suggest model supports NER regulates choice DNA pathway nearby