[Methylation of the genes for the microRNAs miR-129-2 and miR-9-1, changes in their expression, and activation of their potential target genes in clear cell renal cell carcinoma].
作者： IV Pronina , EA Klimov , AM Burdennyy , EV Beresneva , MV Fridman
DOI: 10.1134/S0026893316060169
关键词:
摘要: Methylation of promoter CpG islands and microRNA (miRNA) interactions with mRNAs target genes are epigenetic mechanisms that play a crucial role in deregulation gene expression signaling pathways tumors. Altered six chromosome 3p (RARB(2), SEMA3B, RHOA, GPX1, NKIRAS1, CHL1) two miRNA (MIR-129-2 MIR-9-1) was observed primary clear cell renal carcinomas (ccRCCs, 31-48 samples) by RT-PCR qPCR. Significant downregulation (p < 0.05, Fisher's exact test) for CHL1; differential expression, the other genes. Methylation-specific PCR primers to RARB(2), MIR-129-2, MIR-9-1 showed their methylation frequency significantly elevated ccRCC samples. correlations between were confirmed SEMA3B first time MIR-129-2 (Spearman's correlation coefficient rs ranging 0.31-0.60, p 0.05). The RARB(2) frequencies correlated progression. upregulation CHL1 (rs 0.35-0.53, findings implicate regulating indicate miR-129-2 its affect expression.
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