Methylation profile of group of miRNA genes in clear cell renal cell carcinoma and their involvement in cancer progression

摘要: MicroRNA regulates gene expression, is involved in many cellular processes, and plays an important role the development of cancer. The regulation expression miRNA genes can be achieved by methylating their CpG islands, which shown different types tumors. methylation clear cell renal carcinoma (CCRCC) has mainly been studied for miR-9 miR-34 families. six (miR-124a-2, -124a-3, -9-1, -9-3, -34b/c, -129-2) was analyzed with using a representative sample (46 cases). Methylation three miR -124a-2, -129-2 kidney tumors first time. analysis performed methyl specific PCR. It that frequency changed from 37% to 65% tumor samples significantly higher than histologically normal tissue (P ≤ 3 × 10−5 Fisher’s exact test). These results suggest properties suppressors indicated CCRCC. We also found correlations between some signs progression CCRCC (tumor size, clinical stage, loss differentiation, metastasis).