The effects of concurrent administration of +/-3,4-methylenedioxymethamphetamine and cocaine on conditioned place preference in the adult male rat.

摘要: Conditioned place preference (CPP), a commonly used model for studying the role of contextual cues in drug reward and seeking, was employed to explore possible behavioral interactions between (±)3,4-methylenedioxymethamphetamine (MDMA; “ecstasy”) cocaine. On each four occasions, adult male rats received one three doses MDMA (0 mg/kg, 5 10 mg/kg; administered subcutaneously [s.c.]) combined with cocaine 2.5 intraperitoneally [i.p.]), were then tested CPP paradigm. The results showed MDMA-induced at unit dose but mg/kg there return baseline (control) performance levels. For alone, increased linear fashion as increased. Concurrent administration resulted antagonism drug, evidence that this pattern reversible higher respective drugs. These data are instructive insofar they suggest neurochemical effects presented isolation dramatically altered when two drugs combination.