High-fat diet withdrawal modifies alcohol preference and transcription of dopaminergic and GABAergic receptors.
作者： Luana Martins de Carvalho , Juliana Lauar Gonçalves , Agatha Sondertoft Braga Pedersen , Samara Damasceno , Renato Elias Moreira Júnior
DOI: 10.1080/01677063.2018.1526934
关键词:
摘要: The bidirectional and positive relation between the ingestion of fat alcohol has become subject extensive discussion. However, this is more studied in animal models binge eating with intermittent access high-fat diet or a model short period consumption. Here, we developed to elucidate how chronic its withdrawal influence intake (two-bottle choice) anxiety behavior (marble burying test). In first experimental stage, animals were fed on standard (AIN93G) high sugar butter (HSB) for 8 weeks. Then, protocol free-choice water 10% solution was introduced, HSB replaced AIN93G two groups. result obtained point out that among consumption appears depend presence absence when evaluated, an imbalance mesocorticolimbic dopaminergic pathway, observed by transcriptional regulation dopamine receptors (Drd1/Drd2) GABAB subunit (Gabbr1/Gabbr2), can be driving intake.
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