Role of p38 MAP kinases and ERK in mediating ultraviolet-B induced cyclooxygenase-2 gene expression in human keratinocytes
作者： Weixing Chen , Qingbo Tang , Melissa S Gonzales , G Tim Bowden
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摘要: The roles of p38 MAP kinases and ERK in UVB induced cox-2 gene expression were studied a human keratinocyte cell line, HaCaT. significantly increased at both protein mRNA levels. As we reported previously, activated after irradiation HaCaT cells. In addition, treating the cells with inhibitor SB202190 or MEK PD98059 specifically inhibited activation, respectively. this study, further examined We found that strongly COX-2 different time points various doses. Furthermore, markedly mRNA. Our data indicated did not play role keratinocytes since suppression alter increase These results suggested, for first time, activation is required keratinocytes. Since plays an important UV carcinogenesis, could be potential molecular target chemoprevention skin cancer.
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