How do oncoprotein mutations rewire protein–protein interaction networks?
作者： Emily H Bowler , Zhenghe Wang , Rob M Ewing
DOI: 10.1586/14789450.2015.1084875
关键词:
摘要: The acquisition of mutations that activate oncogenes or inactivate tumor suppressors is a primary feature most cancers. Mutations directly alter protein sequence and structure drive the development tumors through aberrant expression modification proteins, in many cases impacting components signal transduction pathways cellular architecture. Cancer-associated may have direct indirect effects on proteins their interactions while signaling been widely studied, how underlying protein–protein interaction networks much less well understood. Systematic mapping oncoprotein using proteomics techniques as computational network analyses revealing perturb cancer phenotype.
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