Rhabdomyosarcoma in a child with nephrotic syndrome treated with cyclosporine: a case report with literature review.

摘要: In patients with frequently relapsing nephrotic syndrome, immunosuppressive therapy such as cyclosporine are often required to maintain remission. Cyclosporine has been noted have tumorgenesis effects. this case report, we present a child syndrom developed rhabdomyosarcoma on her tongue after adout 4 years of continual therapy. A 2-year-old female had syndrome (urine protein-creatinine ratio 749.1 mg/mg; blood urea nitrogen 11 mg/dL; serum creatinine 0.3 mg/dL; and albumin 1.8 g/dL.) Proteinuria resolved treatment daily prednisolone for weeks at the dose 45 mg (2.5 mg/kg/day) but recurred taper from 25 mg/day 10 mg/day. At least five more episodes relapse occurred within about 3-year period. After third relapse, she was treated (at initial 50 mg/day [1.7 mg/kg/day]) immunosuppression. About diagnosis made, an embryonal tongue. The cancer TPOG-RMS-LR protocol, vincristine, actinomycin, cyclophosphamide. Magnetic resonance imaging scan, performed 3 start therapy, revealed complete remission cancer. Although cannot be conclusively implicated cause in patient, association should prompt consideration its use children.