Cox-2 promotes mesenchymal stem cells differentiation into cardiocytes by activating JNK and ERK pathway.
作者： Ying Zhang , Juan Wang , Zhongying Lv , Dong Zhao , Mei Luo
DOI: 10.1016/J.BBRC.2016.09.163
关键词:
摘要: Coronary heart disease and various cardiomyopathys may cause myocardial damage, reducing the number of cells with complete functions. Cyclooxygenase 2 (Cox-2) has been reported participating in a variety pathological processes, including tumor invasion metastasis. In this study, we sought to explore correlation Cox-2 MSCs proliferation, migration. were transfected pcDNA-Cox2 NS-398 promote or inhibit expression Cox2. Then, MTT, transwell, qRT-PCR western blot used test influence Cox2 on migration cell viability mesenchymal stem. The results show that promotes directional differentiation overexpression cox-2 can activate key factors JNK ERK signaling pathway, differentiation.
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