Genetic variation rs10484761 on 6p21.1 derived from a genome-wide association study is associated with gastric cancer survival in a Chinese population.
作者： Meiyun Kang , Xiaojie Ding , Ming Xu , Haixia Zhu , Sang Liu
DOI: 10.1016/J.GENE.2013.11.087
关键词:
摘要: Abstract A recent genome-wide association study (GWAS) on esophageal squamous-cell carcinoma (ESCC) among Chinese people has discovered a novel single nucleotide polymorphism (SNP) rs10484761 6p21.1 region. We hypothesized that SNP T/C is associated with survival of gastric cancer. genotyped in 940 cancer patients treated surgical resection. Kaplan–Meier analysis, log-rank test, and Cox proportional hazard models were used to evaluate the between survival. In dominant model, those who carry TC/CC genotypes had significant shorter time (log-rank P = 0.005), especially subgroups aged male patients, cardia intestinal tumor (HR = 1.41, 95% CI = 1.08–1.84 for HR = 1.64, CI = 1.14–2.37 intestinal-type), size ≤ 5 cm CI = 0.56–0.99), T1 depth invasion (HR = 2.34, CI = 1.20–4.56), lymph node metastasis (HR = 1.51, CI = 1.19–1.96), no distant (HR = 1.33, CI = 1.05–1.68), TNM stage III + IV (HR = 1.50, CI = 1.13–1.98), chemotherapy (HR = 1.53, CI = 1.17–1.99). The results indicated was prognosis cancer, suggesting this genetic variant may serve as potential marker predict population.
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