Clinical implications of chromosomal abnormalities in gastric adenocarcinomas.
作者： Chew-Wun Wu , Gen-Der Chen , Cathy S.-J. Fann , Anna F.-Y. Lee , Chin-Wen Chi
DOI: 10.1002/GCC.10106
关键词:
摘要: Gastric carcinoma (GC) is one of the most common malignancies worldwide and has a very poor prognosis. Genetic imbalances in 62 primary gastric adenocarcinomas various histopathologic types pathologic stages six cancer-derived cell lines were analyzed by comparative genomic hybridization, relationship abnormalities to clinical features GC was evaluated at genome-wide level. Eighty-four percent tumors all showed DNA copy number changes. The recurrent chromosomal including gains 15 regions losses 8 identified. Statistical analyses revealed that 17q24-qter (53 percent), 20q13-qter (48 1p32-p36 (42 22q12-qter (27 17p13-pter (24 16p13-pter (21 6p21-pter (19 20p12-pter 7p21-pter (18 3q28-qter (8 13q13-q14 18q12-qter (11 3p12 3p25-pter 5q14-q23 9p21-p23 (5 are associated with unique patient or tumor-related features. GCs differing shown be distinct patterns genetic alterations, supporting notion they evolve through pathways. Metastatic also specific These may harbor candidate genesmore » involved pathogenesis this malignancy.« less
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