Structural Integrity of the Uncinate Fasciculus and Resting State Functional Connectivity of the Ventral Prefrontal Cortex in Late Life Depression

摘要: Background Neuroimaging studies in late life depression have reported decreased structural integrity of white matter tracts the prefrontal cortex. Functional identified changes functional connectivity among several key areas involved mood regulation. Few combined and imaging. In this study we sought to examine relationship between uncinate fasciculus, a fronto-temporal tract resting state ventral cortex ((PFC) limbic striatal areas. Methods The sample consisted 24 older patients remitted from unipolar major depression. Each participant had magnetic resonance imaging brain scan using standardized protocols obtain both diffusion tensor data. Our statistical approach compared fasciculus data. Results We found positive correlations left (UF) fractional anisotropy (FA) (rsFC) ventrolateral PFC amygdala hippocampus. addition, significant negative correlation ventromedial PFC-caudate rsFC UF FA. The right FA did not correlate with any seed region based connectivity. Conclusions These results support notion that reflects integrity, since is structurally connected temporal regions by UF. Future should include larger samples healthy comparison subjects which task-based are examined.