Metabolic Control of Autophagy

摘要: Macroautophagy (herein referred to as autophagy) is an evolutionarily conserved mechanism of adaptation adverse microenvironmental conditions, including limited nutrient supplies. Several sensors interacting with the autophagic machinery have evolved detect fluctuations in key metabolic parameters. The signal transduction cascades operating downstream these are highly interconnected control a spatially and chronologically coordinated response that maintains health function individual cells while preserving organismal homeostasis. Here, we discuss physiological regulation autophagy by circuitries, well alterations such disease.