Long non-coding RNA RFPL3S is a novel prognostic biomarker in lung cancer.

作者: Zhonghua Liu , Zhiqiang Ning , Hailin Lu , Tinghua Cao , Feng Zhou

DOI: 10.3892/OL.2020.11642

关键词:

摘要: Long non-coding RNAs (lncRNAs) are functional components of the human genome. Recent studies have demonstrated that lncRNAs play essential roles in tumorigenesis, and involved cell proliferation, apoptosis, migration invasion several types tumor, including lung cancer. However, clinical relevance lncRNA expression cancer remains unknown. The aim present study was to investigate pattern RFPL3 antisense (RFPL3S) its associations with clinicopathological characteristics patients Whether RFPL3S can act as a potential prognostic biomarker for also investigated. tumor samples cells assessed using Oncomine database Cancer Cell Line Encyclopedia, respectively. Based on Kaplan-Meier Plotter analyses, values were further evaluated. It revealed highly expressed tissues when compared normal significantly associated pN factor, pTNM stage Ki-67 labeling index. In survival increased poor inversely first progression all patients. These results indicate may be significance

参考文章(63)
Feng Yang, Jianwei Bi, Xuchao Xue, Luming Zheng, Kangkang Zhi, Jide Hua, Guoen Fang, Up-regulated long non-coding RNA H19 contributes to proliferation of gastric cancer cells. FEBS Journal. ,vol. 279, pp. 3159- 3165 ,(2012) , 10.1111/J.1742-4658.2012.08694.X
JINGXU SUN, YONGXI SONG, XIAOWAN CHEN, JUNHUA ZHAO, PENG GAO, XUANZHANG HUANG, HUIMIAN XU, ZHENNING WANG, Novel long non-coding RNA RP11-119F7.4 as a potential biomarker for the development and progression of gastric cancer Oncology Letters. ,vol. 10, pp. 115- 120 ,(2015) , 10.3892/OL.2015.3186
Yu Qin, Wangbing Chen, Yao Xiao, Wendan Yu, Xin Cai, Meng Dai, Tingting Xu, Wenlin Huang, Wei Guo, Wuguo Deng, Taihua Wu, RFPL3 and CBP synergistically upregulate hTERT activity and promote lung cancer growth. Oncotarget. ,vol. 6, pp. 27130- 27145 ,(2015) , 10.18632/ONCOTARGET.4825
Wangbing Chen, Jianjun Lu, Yu Qin, Jingshu Wang, Yun Tian, Dingbo Shi, Shusen Wang, Yao Xiao, Meng Dai, Lu Liu, Guo Wei, Taihua Wu, Bilian Jin, Xiangsheng Xiao, Tie-Bang Kang, Wenlin Huang, Wuguo Deng, Ret finger protein-like 3 promotes tumor cell growth by activating telomerase reverse transcriptase expression in human lung cancer cells Oncotarget. ,vol. 5, pp. 11909- 11923 ,(2014) , 10.18632/ONCOTARGET.2557
Mitchell Guttman, John L. Rinn, Modular regulatory principles of large non-coding RNAs Nature. ,vol. 482, pp. 339- 346 ,(2012) , 10.1038/NATURE10887
Tony Gutschner, Sven Diederichs, The hallmarks of cancer: a long non-coding RNA point of view. RNA Biology. ,vol. 9, pp. 703- 719 ,(2012) , 10.4161/RNA.20481
Thanyanan Reungwetwattana, Saravut J. Weroha, Julian R. Molina, Oncogenic Pathways, Molecularly Targeted Therapies, and Highlighted Clinical Trials in Non–Small-Cell Lung Cancer (NSCLC) Clinical Lung Cancer. ,vol. 13, pp. 252- 266 ,(2012) , 10.1016/J.CLLC.2011.09.004
ZhaoJian Gong, ShanShan Zhang, WenLing Zhang, HongBin Huang, Qiao Li, Hao Deng, Jian Ma, Ming Zhou, JuanJuan Xiang, MingHua Wu, XiaYu Li, Wei Xiong, XiaoLing Li, Yong Li, ZhaoYang Zeng, GuiYuan Li, Long non-coding RNAs in cancer Science China Life Sciences. ,vol. 55, pp. 1120- 1124 ,(2012) , 10.1007/S11427-012-4413-9
Xin-yu Fang, Hai-feng Pan, Rui-xue Leng, Dong-qing Ye, Long noncoding RNAs: novel insights into gastric cancer. Cancer Letters. ,vol. 356, pp. 357- 366 ,(2015) , 10.1016/J.CANLET.2014.11.005
Young Lim Choi, Manabu Soda, Yoshihiro Yamashita, Toshihide Ueno, Junpei Takashima, Takahiro Nakajima, Yasushi Yatabe, Kengo Takeuchi, Toru Hamada, Hidenori Haruta, Yuichi Ishikawa, Hideki Kimura, Tetsuya Mitsudomi, Yoshiro Tanio, Hiroyuki Mano, EML4-ALK Mutations in Lung Cancer That Confer Resistance to ALK Inhibitors The New England Journal of Medicine. ,vol. 363, pp. 1734- 1739 ,(2010) , 10.1056/NEJMOA1007478