Circulating exosomal miR-92b: Its role for cancer immunoediting and clinical value for prediction of posttransplant hepatocellular carcinoma recurrence.
作者： Toshiaki Nakano , I‐Hsuan Chen , Chih‐Chi Wang , Po‐Jung Chen , Hui‐Peng Tseng
DOI: 10.1111/AJT.15490
关键词:
摘要: A recurrence of hepatocellular carcinoma (HCC) after living donor liver transplantation (LDLT) is one the major concerns reflecting higher mortality HCC. This study aimed to explore impact circulating exosomes on HCC development and recurrence. One-shot transfusion hepatoma serum naive rats induced cancer with gradual elevation alpha-fetoprotein (AFP), but exosome-free failed induce AFP elevation. The microarray analysis revealed miR-92b as highly expressing microribonucleic acids in exosomes. Overexpression enhanced migration ability cell lines active release exosomal miR-92b. hepatoma-derived transferred natural killer (NK) cells, resulting downregulation CD69 NK cell-mediated cytotoxicity. Furthermore, expression was confirmed patients before LDLT, its value at 1 month LDLT maintained a level posttransplant In summary, we demonstrated development, partly through suppression cells by may predict risk
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