Modulation of cellular immunity by a lesion of the lateral hypothalamic area (LHA) in rats
作者： W. Juzwa , G. Gnacińska , I. Rawicz-Zegrzda , J. Kaczmarek
DOI: 10.1016/S0940-2993(11)80358-1
关键词:
摘要: The subject of our investigation was the effect bilateral damage to lateral hypothalamic area (LHA) on cellular immune response (CIR), assessed by measuring diameter skin infiltration (DSI) 24 and 48 h after intradermal administration tuberculin in adult male Wistar rats, previously immunized with BCG vaccine. It has been shown that: 1) hypothalamo-lesioned rats (HLR) DSI measured tuberculinization did not differ, 2) sham-operated (SOR) injection significantly higher (p < 0.02) than that found antigen administration, 3) damage-induced loss body weight 24-48 difference responders HLR group correlated negatively each other (r = -0.806, p 0.05). These results indicate LHA enhances rate formation, but maximal size, tuberculin-induced infiltration. Thus, seems be involved regulation/modulation processes engaged expression reaction.
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