Substantia nigra 6-OHDA lesions mimic striatopallidal disruption of syntactic grooming chains: A neural systems analysis of sequence control

摘要: It has been suggested that the coordination of complex sequences behavior requires normal nigrostriatal function. A previous study showed kainic acid lesions corpus striatum can disrupt performance natural, untrained stereotyped (syntactic chains), which occur regularly during rodent grooming. In this study, intranigral injections 6-OHDA were used to destroy dopamine projections in order deplete dopaminergic inputs. Striatal depletion was found effective completion syntactic grooming chains. Syntactic chain disruption correlated with aphagia follows depletion. These data compared those from studies after striatal damage, sensory deafferentation, and decerebration at various levels brainstem. comparisons indicated loss either or intrinsic neurons produced equivalent also component system disrupted chaining a degree equal by entire forebrain. results suggest integrity systems is crucial forebrain implementation sequence.