Minireview: Basal-Like Breast Cancer: From Molecular Profiles to Targeted Therapies

摘要: The classification of breast cancer into molecular subtypes with distinctive gene expression signatures that predict treatment response and prognosis has ushered in a new era personalized medicine for this remarkably heterogeneous deadly disease. Basal-like (BLBC) is particularly aggressive subtype defined by robust cluster genes expressed epithelial cells the basal or outer layer adult mammary gland. BLBC major clinical challenge because these tumors are prevalent young woman, often relapsing rapidly. Additionally, most (but not all) basal-like lack steroid hormone receptors (estrogen receptor progesterone receptor) human epidermal growth factor 2, limiting targeted therapeutic options predominantly triple-negative cancers. This minireview will focus on insights etiology poor-prognosis underlie their intrinsic genomic instability, deregulated cell proliferation apoptosis, invasive tumor biology. We also review ongoing efforts to translate fundamental improved therapies women BLBC.