Determination of Mycoplasma hyopneumoniae-Specific IgG, IgG1, and IgG2a Titers in BALB/c Mice Induced by Mineral Oil-Based Oil-in-Water Emulsion Adjuvants Prepared Using a Self-Emulsifying Drug Delivery System.
作者： Rakesh Bastola , Jo-Eun Seo , Gyubin Noh , Taekwang Keum , Ju Hun Kim
DOI: 10.1208/S12249-018-1245-3
关键词:
摘要: We prepared mineral oil-based emulsion adjuvants by employing simple self-emulsifying drug delivery system (SEDDS). Mineral oil emulsions (3%, 5%, and 7%) were using deionized water C-971P NF C-940 grade carbomer solutions with concentrations 0.01% (w/v) 0.02% (w/v). In total, 15 mixed a solution containing inactivated Mycoplasma hyopneumoniae (J101 strain) antigen porcine circovirus type 2 to prepare vaccines. Droplet sizes in the submicron range zeta potential values between − 40 0 mV maintained most for period of 6 months. Emulsion regarded safe, their M. hyopneumoniae-specific IgG, IgG1, IgG2a titers either better or comparable those aluminum gel.
springer.com
sci-hub.se 参考文章(17)
Yunpeng Fan, Xia Ma, Lin Ma, Jing Zhang, Weimin Zhang, Xiaoping Song, Antioxidative and immunological activities of ophiopogon polysaccharide liposome from the root of Ophiopogon japonicus Carbohydrate Polymers. ,vol. 135, pp. 110- 120 ,(2016) , 10.1016/J.CARBPOL.2015.08.089
Ziheng Wang, Rajinder Pal, Enlargement of Nanoemulsion Region in Pseudo-ternary Mixing Diagrams for a Drug Delivery System Journal of Surfactants and Detergents. ,vol. 17, pp. 49- 58 ,(2014) , 10.1007/S11743-013-1497-6
Pushp R. Nepal, Hyo-Kyung Han, Hoo-Kyun Choi, Preparation and in vitro–in vivo evaluation of Witepsol® H35 based self-nanoemulsifying drug delivery systems (SNEDDS) of coenzyme Q10 European Journal of Pharmaceutical Sciences. ,vol. 39, pp. 224- 232 ,(2010) , 10.1016/J.EJPS.2009.12.004
L. Stipkovits, G. Czifra, B. Sundquist, Indirect ELISA for the detection of a specific antibody response against Mycoplasma gallisepticum. Avian Pathology. ,vol. 22, pp. 481- 494 ,(1993) , 10.1080/03079459308418937
Felix Ostertag, Jochen Weiss, David Julian McClements, Low-energy formation of edible nanoemulsions: Factors influencing droplet size produced by emulsion phase inversion joint international conference on information sciences. ,vol. 388, pp. 95- 102 ,(2012) , 10.1016/J.JCIS.2012.07.089
Christopher B. Fox, Ryan C. Anderson, Timothy S. Dutill, Yasuyuki Goto, Steven G. Reed, Thomas S. Vedvick, Monitoring the effects of component structure and source on formulation stability and adjuvant activity of oil-in-water emulsions Colloids and Surfaces B: Biointerfaces. ,vol. 65, pp. 98- 105 ,(2008) , 10.1016/J.COLSURFB.2008.03.003
A. Galliher-Beckley, L.K. Pappan, Rachel Madera, Y. Burakova, A. Waters, M. Nickles, X. Li, J. Nietfeld, J.R. Schlup, Q. Zhong, S. McVey, S.S. Dritz, J. Shi, Characterization of a novel oil-in-water emulsion adjuvant for swine influenza virus and Mycoplasma hyopneumoniae vaccines. Vaccine. ,vol. 33, pp. 2903- 2908 ,(2015) , 10.1016/J.VACCINE.2015.04.065
Luis A. Brito, Padma Malyala, Derek T. O’Hagan, Vaccine adjuvant formulations: a pharmaceutical perspective. Seminars in Immunology. ,vol. 25, pp. 130- 145 ,(2013) , 10.1016/J.SMIM.2013.05.007
K.H. Mair, H. Koinig, W. Gerner, A. Höhne, J. Bretthauer, J.J. Kroll, M.B. Roof, A. Saalmüller, K. Stadler, R. Libanova, Carbopol improves the early cellular immune responses induced by the modified-life vaccine Ingelvac PRRS® MLV. Veterinary Microbiology. ,vol. 176, pp. 352- 357 ,(2015) , 10.1016/J.VETMIC.2015.02.001
M.K. Naskar, D. Kundu, M. Chatterjee, Effect of process parameters on surfactant-based synthesis of hydroxy sodalite particles Materials Letters. ,vol. 65, pp. 436- 438 ,(2011) , 10.1016/J.MATLET.2010.11.008