Calcium phosphate cement reinforcement by polymer infiltration and in situ curing: a method for 3D scaffold reinforcement.

摘要: This study describes a novel method of calcium phosphate cement reinforcement based on infiltrating pre-set with reactive polymer and then cross-linking the in situ. can be used to reinforce 3D scaffolds, which we demonstrate using poly(ethylene glycol) diacrylate (PEGDA) as model reinforcing polymer. The compressive strength scaffold comprised orthogonally intersecting beams was increased from 0.31 ± 0.06 MPa 1.65 0.13 PEGDA 600. In addition, mechanical properties reinforced were characterized three molecular weights (200, 400, 600 Da) powder liquid (P/L) ratios (0.8, 1.0, 1.43). Higher weight efficacy, P/L controlled porosity determined extent incorporation. Although increasing incorporation resulted transition brittle, cement-like behavior ductile, polymer-like behavior, maximizing not advantageous. Polymerization shrinkage produced microcracks cement, reduced properties. most effective achieved 1.43 this group, flexural 0.44 0.12 7.04 0.51 MPa, maximum displacement 0.05 0.01 mm 1.44 0.17 mm, work fracture 0.64 0.10 J/m2 677.96 70.88 compared non-reinforced controls. These results effectiveness our method, well its potential for fabricating scaffolds useful bone tissue engineering. © 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part A,