A Review of Osteocyte Function and the Emerging Importance of Sclerostin

摘要: ➤ Osteocytes, derived from osteoblasts, reside within bone and communicate extensively with other cell populations to regulate metabolism. The mature osteocyte expresses the protein sclerostin, a negative regulator of mass.➤ In normal physiologic states, sclerostin acts on osteoblasts at surface is differentially expressed in response mechanical loading, inflammatory molecules such as prostaglandin E2, hormones parathyroid hormone estrogen.➤ Pathologically, dysregulation has been observed osteoporosis-related fractures, failure implant osseous integration, metastatic disease, select genetic diseases An antibody that targets decreasing endogenous levels while increasing mineral density, currently phase-III clinical trials.➤ emerged versatile, indispensable cell. Its location bone, extensive dendritic network, close communication systemic circulation cells produce many opportunities treat variety orthopaedic conditions.