Occupational health hazards of trichloroethylene among workers in relation to altered mRNA expression of cell cycle regulating genes (p53, p21, bax and bcl-2) and PPARA
作者： Meenu Varshney , Abhijit Chandra , Rajeev Jain , Riaz Ahmad , Vipin Bihari
DOI: 10.1016/J.TOXREP.2015.04.002
关键词:
摘要: Abstract Trichloroethylene (TCE) is widely used as a metal degreaser in industrial processes. The present study reports on the effects of TCE exposure workers employed lock industries. To ensure to TCE, its toxic metabolites, trichloroacetic acid (TCA), dichloroacetic (DCA) and trichloroethanol (TCEOH) were detected plasma subjects through solid phase microextraction-gas chromatography-electron capture detection. TCA, DCA TCEOH range 0.004–2.494 μg/mL, 0.01–3.612 μg/mL 0.002–0.617 μg/mL, respectively. Quantitative reverse transcription polymerase chain reaction analysis revealed up-regulated expression p53 (2.4-fold; p
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