Personalised Medicine: Genome Maintenance Lessons Learned from Studies in Yeast as a Model Organism.
作者： Arwa A. Abugable , Dahlia A. Awwad , Dalia Fleifel , Mohamed M. Ali , Sherif El-Khamisy
DOI: 10.1007/978-3-319-60733-7_9
关键词:
摘要: Yeast research has been tremendously contributing to the understanding of a variety molecular pathways due ease its genetic manipulation, fast doubling time as well being cost-effective. The these did not only help scientists learn more about cellular functions but also assisted in deciphering and defects behind multiple diseases. Hence, yeast opened doors for transforming basic into applied research, paved roads improving diagnosis innovating personalized therapy different In this chapter, we discuss how contributed major genome maintenance such S-phase checkpoint activation pathways, repair via homologous recombination non-homologous end joining topoisomerases-induced protein linked DNA breaks repair. Defects lead neurodegenerative diseases cancer. Thus, exact underlying allowed development medicine, treatment overcoming detriments current conventional therapies side effects, toxicity drug resistance.
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sci-hub.se 参考文章(285)
A.E. Tomkinson, E. Roberts, G. Daly, N.F. Totty, T. Lindahl, Three distinct DNA ligases in mammalian cells. Journal of Biological Chemistry. ,vol. 266, pp. 21728- 21735 ,(1991) , 10.1016/S0021-9258(18)54697-4
Rui Gao, Matthew J. Schellenberg, Shar-yin N. Huang, Monica Abdelmalak, Christophe Marchand, Karin C. Nitiss, John L. Nitiss, R. Scott Williams, Yves Pommier, Proteolytic Degradation of Topoisomerase II (Top2) Enables the Processing of Top2·DNA and Top2·RNA Covalent Complexes by Tyrosyl-DNA-Phosphodiesterase 2 (TDP2) Journal of Biological Chemistry. ,vol. 289, pp. 17960- 17969 ,(2014) , 10.1074/JBC.M114.565374
Yves Pommier, Juana M. Barcelo, V. Ashutosh Rao, Olivier Sordet, Andrew G. Jobson, Laurent Thibaut, Ze‐Hong Miao, Jennifer A. Seiler, Hongliang Zhang, Christophe Marchand, Keli Agama, John L. Nitiss, Christophe Redon, Repair of topoisomerase I-mediated DNA damage. Progress in Nucleic Acid Research and Molecular Biology. ,vol. 81, pp. 179- 229 ,(2006) , 10.1016/S0079-6603(06)81005-6
David Botstein, Tim Stearns, Hong Ma, Manipulating yeast genome using plasmid vectors. Methods in Enzymology. ,vol. 185, pp. 280- 297 ,(1990) , 10.1016/0076-6879(90)85025-J
Weixing Zhao, Sivaraja Vaithiyalingam, Joseph San Filippo, David G. Maranon, Judit Jimenez-Sainz, Gerald V. Fontenay, Youngho Kwon, Stanley G. Leung, Lucy Lu, Ryan B. Jensen, Walter J. Chazin, Claudia Wiese, Patrick Sung, Promotion of BRCA2-Dependent Homologous Recombination by DSS1 via RPA Targeting and DNA Mimicry Molecular Cell. ,vol. 59, pp. 176- 187 ,(2015) , 10.1016/J.MOLCEL.2015.05.032
Ulf Grawunder, Matthias Wilm, Xiantuo Wu, Peter Kulesza, Thomas E Wilson, Matthias Mann, Michael R Lieber, None, Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells Nature. ,vol. 388, pp. 492- 495 ,(1997) , 10.1038/41358
Gwenola Manic, Florine Obrist, Antonella Sistigu, Ilio Vitale, Trial Watch: Targeting ATM–CHK2 and ATR–CHK1 pathways for anticancer therapy Molecular and Cellular Oncology. ,vol. 2, ,(2015) , 10.1080/23723556.2015.1012976
Yosef Shiloh, Michael B. Kastan, ATM: Genome stability, neuronal development, and cancer cross paths Advances in Cancer Research. ,vol. 83, pp. 209- 254 ,(2001) , 10.1016/S0065-230X(01)83007-4
Yves Pommier, Thomas Dexheimer, Kasthuraiah Maddali, Christophe Marchand, Periyasamy Selvam, Fluoroquinolone derivatives or sulfonamide moiety-containing compounds as inhibitors of tyrosyl-dnaphosphodiesterase (TDP1) ,(2011)
Philip J. Tofilon, Kevin Camphausen, Michael A. Cerra, Kelli A. Oswald, William E. Burgan, Kristin Brady, Jeffery S. Russell, Gleevec-Mediated Inhibition of Rad51 Expression and Enhancement of Tumor Cell Radiosensitivity Cancer Research. ,vol. 63, pp. 7377- 7383 ,(2003)