Down-regulation of a serine protease, myeloblastin, causes growth arrest and differentiation of promyelocytic leukemia cells
作者： Dominique Bories , Marie-Cecile Raynal , David H. Solomon , Zbigniew Darzynkiewicz , Yvon E. Cayre
DOI: 10.1016/0092-8674(89)90752-6
关键词:
摘要: Cells from the human leukemia cell line HL-60 undergo terminal differentiation when exposed to inducing agents. Differentiation of these cells is always accompanied by withdrawal cycle. Here we describe isolation a cDNA encoding novel serine protease that present in and down-regulated during induced cells. We have named this myeloblastin. Down-regulation myeloblastin mRNA occurs with both monocytic granulocytic inducers. Myeloblastin undetectable fully differentiated as well peripheral blood monocytes. found regulation serum dependent. Inhibition expression an antisense oligodeoxynucleotide inhibits proliferation induces promyelocyte-like
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