Inhibitory effects of tea polyphenols by targeting cyclooxygenase-2 through regulation of nuclear factor kappa B, Akt and p53 in rat mammary tumors

摘要: Breast cancer has become the second leading cause of cancer-related deaths worldwide. The control this disease can be achieved through chemoprevention, which refers to consumption synthetic or naturally occurring agents block, reverse, delay process tumor development. Tea (Camellia sinensis), most widely consumed beverage, shown promises in field chemoprevention. Inhibition tumorigenesis by green black tea polyphenols been demonstrated various vitro and vivo models. Here, we examined inhibitory effect polyphenol (GTP) (BTP) on development mammary tumors- induced 7, 12-dimethylbenz (a) anthracene (DMBA) female, Wistar rats. 13% 33% animals developed tumors GTP BTP supplemented groups, respectively. Both are effective significantly inhibiting cumulative number (by ~92% 77%, respectively) reducing their growth. Mechanistically, investigated effects components cell signaling pathways, connecting biomolecules involved supplementation as a sole source drinking solution leads scavenging reactive oxygen species (ROS) ~72% 69%, cyclooxygenase-2 (Cox-2) inactivation phosphorylated forms nuclear factor-kappa B (NF-κB) Akt. Altogether, study suggests that both cultivars tea, i.e. black, have anti-tumorigenic potential against DMBA-induced Further studies such large long term cohort clinical trials warranted.