Mimicry of elastin repetitive motifs by Theileria annulata sporozoite surface antigen

作者: Roger Hall , Philip D. Hunt , Mark Carrington , David Simmons , Susanna Williamson

DOI: 10.1016/0166-6851(92)90012-9

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摘要: Theileria annulata is an important pathogen of cattle in the tropics. The gene sequence a sporozoite surface antigen (SPAG-1) reported. Data also presented demonstrating that SPAG-1 synthesised as large precursor. This antigen, which candidate for inclusion subunit vaccine, shows remarkable degree molecular mimicry to extracellular matrix protein elastin. It contains both repetitive motifs PGVGV and VGVAPG. Immunofluorescence using monoclonal antibody against VGVAPG confirmed this peptide expressed on sporozoites predicted. presence particularly interesting since ligand elastin receptors range cell types, including macrophages/monocytes are major class host target cells. proposed represents whereby T. recognises its

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