Genomics and metagenomics in medical microbiology.

摘要: Over the last two decades, sequencing tools have evolved from laborious time-consuming methodologies to real-time detection and deciphering of genomic DNA. Genome sequencing, especially using next generation (NGS) has revolutionized landscape microbiology infectious disease. This deluge data not only enabled advances in fundamental biology but also helped improve diagnosis, typing pathogen, virulence antibiotic resistance detection, development new vaccines culture media. In addition, NGS efficient analysis complex human micro-floras, both commensal, pathological, through metagenomic methods, thus helping comprehension management diseases such as obesity. review summarizes technological genomics metagenomics relevant field medical microbiology.