Facile synthesis of 3-(2-furanyl)indoles via a multicomponent reaction

作者: Chang Sun , Shun-Jun Ji , Yu Liu

DOI: 10.1016/J.TETLET.2007.10.098

关键词:

摘要: Abstract 3-(2-Furanyl)indoles were firstly synthesized in a one-pot procedure by the reaction of 3-cyanoacetyl indole, aromatic aldehydes and isocyanides ethanol presence ammonium acetate.

参考文章(14)
Richard J. Sundberg, The chemistry of indoles ,(1970)
Alexander Dömling, Recent advances in isocyanide-based multicomponent chemistry Current Opinion in Chemical Biology. ,vol. 6, pp. 306- 313 ,(2002) , 10.1016/S1367-5931(02)00328-9
Malcolm M Campbell, Nicholas Cosford, Li Zongli, Malcolm Sainsbury, A new route to 3-heteroarylindoles Tetrahedron. ,vol. 43, pp. 1117- 1122 ,(1987) , 10.1016/S0040-4020(01)90049-3
Ivar Ugi, Alexander Dömling, Werner Hörl, MULTICOMPONENT REACTIONS IN ORGANIC-CHEMISTRY Endeavour. ,vol. 18, pp. 115- 122 ,(1994) , 10.1016/S0160-9327(05)80086-9
Lutz Weber, Multi-component reactions and evolutionary chemistry. Drug Discovery Today. ,vol. 7, pp. 143- 147 ,(2002) , 10.1016/S1359-6446(01)02090-6
Alexander Dömling, Ivar Ugi, Multicomponent Reactions with Isocyanides. Angewandte Chemie. ,vol. 39, pp. 3168- 3210 ,(2000) , 10.1002/1521-3773(20000915)39:18<3168::AID-ANIE3168>3.0.CO;2-U
Geneviève Balme, Emmanuel Bossharth, Nuno Monteiro, Pd‐Assisted Multicomponent Synthesis of Heterocycles European Journal of Organic Chemistry. ,vol. 2003, pp. 4101- 4111 ,(2003) , 10.1002/EJOC.200300378
Axel Jacobi von Wangelin, Helfried Neumann, Dirk Gördes, Stefan Klaus, Dirk Strübing, Matthias Beller, Multicomponent Coupling Reactions for Organic Synthesis: Chemoselective Reactions with Amide–Aldehyde Mixtures Chemistry: A European Journal. ,vol. 9, pp. 4286- 4294 ,(2003) , 10.1002/CHEM.200305048
Lutz Weber, The application of multi-component reactions in drug discovery Current Medicinal Chemistry. ,vol. 9, pp. 2085- 2093 ,(2002) , 10.2174/0929867023368719
Shun-Jun Ji, Shun-Yi Wang, Yong Zhang, Teck-Peng Loh, Facile synthesis of bis(indolyl)methanes using catalytic amount of iodine at room temperature under solvent-free conditions Tetrahedron. ,vol. 60, pp. 2051- 2055 ,(2004) , 10.1016/J.TET.2003.12.060