InCl3 mediated one-pot multicomponent synthesis, anti-microbial, antioxidant and anticancer evaluation of 3-pyranyl indole derivatives
作者： Neelakandan Vidhya Lakshmi , Prakasam Thirumurugan , K.M. Noorulla , Paramasivan.T. Perumal
DOI: 10.1016/J.BMCL.2010.07.039
关键词:
摘要: Abstract A simple and convenient method for the one-pot three-component synthesis of 3-pyranyl indoles has been accomplished by tandem Knoevenagel–Michael reaction 3-cyanoacetyl indole, various aromatic aldehydes malononitrile catalyzed InCl3 in ethanol under reflux conditions. The newly synthesized were evaluated anti-microbial, antioxidant, anticancer activities. Some compounds showed good activity against MCF-7 breast cancer cell lines on comparison with standard drug.
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