A one-pot three-component domino protocol for the synthesis of penta-substituted 4H-pyrans
作者： Sathiyamoorthi Sivakumar , Selvaraj Kanchithalaivan , Raju Ranjith Kumar
DOI: 10.1039/C3RA41510D
关键词:
摘要: A library of novel 2-(1H-indol-3-yl)-6-(methylamino)-5-nitro-4-aryl-4H-pyran-3-carbonitriles and 6-(methylamino)-4-(aryl)-5-nitro-2-phenyl-4H-pyran-3-carbonitriles were synthesized in excellent yields via domino one-pot three-component reactions 3-(1H-indol-3-yl)-3-oxopropanenitrile or benzoylacetonitrile, aromatic aldehydes (E)-N-methyl-1-(methylthio)-2-nitroethenamine respectively. This reaction presumably occurs Knoevenagel condensation–Michael addition–intramolecular O-cyclization sequence reactions. The significant advantages this include process, simple work-up procedure, no column chromatographic purification.
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