Probing stress induced phase transformation in aspirin polymorphs using Raman spectroscopy enabled nanoindentation.
作者： Praveena Manimunda , S. A. Syed Asif , Manish Kumar Mishra
DOI: 10.1039/C9CC04538D
关键词:
摘要: Nanoindentation has extensively been used to measure the mechanical properties of molecular crystals. However, possibilities stress induced polymorphic transformation during indentation are still unexplored. Here, we have adopted a spatially synchronized Raman spectroscopy and nanoindentation technique probe in aspirin polymorphs. Spatial hardness maps, generated using an accelerated property mapping technique, showed micro-domain formation form II
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sci-hub.se 参考文章(22)
Soumyajit Ghosh, Arobendo Mondal, M. S. R. N. Kiran, U. Ramamurty, C. Malla Reddy, The Role of Weak Interactions in the Phase Transition and Distinct Mechanical Behavior of Two Structurally Similar Caffeine Co-crystal Polymorphs Studied by Nanoindentation Crystal Growth & Design. ,vol. 13, pp. 4435- 4441 ,(2013) , 10.1021/CG400928V
Andrew D. Bond, Katarzyna A. Solanko, Simon Parsons, Sascha Redder, Roland Boese, Single crystals of aspirin form II: crystallisation and stability CrystEngComm. ,vol. 13, pp. 399- 401 ,(2011) , 10.1039/C0CE00588F
R. Tawashi, Aspirin: Dissolution Rates of Two Polymorphic Forms Science. ,vol. 160, pp. 76- 76 ,(1968) , 10.1126/SCIENCE.160.3823.76
Johannes D. Bauer, Eiken Haussühl, Björn Winkler, Dirk Arbeck, Victor Milman, Struan Robertson, Elastic Properties, Thermal Expansion, and Polymorphism of Acetylsalicylic Acid Crystal Growth & Design. ,vol. 10, pp. 3132- 3140 ,(2010) , 10.1021/CG100241C
Geoff GZ Zhang, Devalina Law, Eric A Schmitt, Yihong Qiu, Phase transformation considerations during process development and manufacture of solid oral dosage forms Advanced Drug Delivery Reviews. ,vol. 56, pp. 371- 390 ,(2004) , 10.1016/J.ADDR.2003.10.009
T. P. Shakhtshneider, V. V. Boldyrev, Phase Transformations in Sulfathiazole During Mechanical Activation Drug Development and Industrial Pharmacy. ,vol. 19, pp. 2055- 2067 ,(1993) , 10.3109/03639049309069341
Ethan L. Crowell, Zbigniew A. Dreger, Yogendra M. Gupta, High-pressure polymorphism of acetylsalicylic acid (aspirin): Raman spectroscopy Journal of Molecular Structure. ,vol. 1082, pp. 29- 37 ,(2015) , 10.1016/J.MOLSTRUC.2014.10.079
Sunil Varughese, MSRN Kiran, Upadrasta Ramamurty, Gautam R Desiraju, None, Nanoindentation in Crystal Engineering: Quantifying Mechanical Properties of Molecular Crystals Angewandte Chemie. ,vol. 52, pp. 2701- 2712 ,(2013) , 10.1002/ANIE.201205002
Manish Kumar Mishra, Gautam R. Desiraju, Upadrasta Ramamurty, Andrew D. Bond, Studying Microstructure in Molecular Crystals With Nanoindentation: Intergrowth Polymorphism in Felodipine Angewandte Chemie. ,vol. 53, pp. 13102- 13105 ,(2014) , 10.1002/ANIE.201406898
Sunil Varughese, MSRN Kiran, Katarzyna A Solanko, Andrew D Bond, U Ramamurty, Gautam R Desiraju, None, Interaction anisotropy and shear instability of aspirin polymorphs established by nanoindentation Chemical Science. ,vol. 2, pp. 2236- 2242 ,(2011) , 10.1039/C1SC00430A