Surgical injury induces local and distant adipose tissue browning

摘要: The adipose organ, which comprises brown, white and beige adipocytes, possesses remarkable plasticity in response to feeding cold exposure. development of adipocytes tissue (WAT), a process called browning, represents promising route treat metabolic disorders. While surgical procedures constantly traumatize tissue, its impact on adipocyte phenotype remains be established. Herein, we studied the effect trauma one day after sham, incision control, or injury left inguinal compartment. Caloric restriction was used control for surgery-associated body temperature changes weight loss. We characterized trauma-induced cellular molecular subcutaneous, visceral, interscapular, perivascular using histology, immunohistochemistry, gene expression, flow cytometry analysis. After day, stimulated browning at site and, importantly, contralateral depot. Browning not present only, largely independent Adipose rapidly recruited monocytes injured promoted alternatively activated macrophages. Conversely, PDGF receptor-positive progenitors were reduced. In this study, identify as an unexpected driver selected local remote holding important implications biologic injury.