Carboxymethylpachymaran, a New Water Soluble Polysaccharide with Marked Antitumour Activity
作者： JUNJI HAMURO , YUMI YAMASHITA , YOKO OHSAKA , YUKIKO Y. MAEDA , GORO CHIHARA
DOI: 10.1038/233486A0
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摘要: WE have reported that the polysaccharides lentinan1,2 and pachymaran3 strongly inhibit growth of sarcoma 180 transplanted in mice, they could be considered as excellent immune-accelerators cell-mediated responses4,5. It is difficult, however, to dissolve them water label with isotopes, their use biological investigations can therefore troublesome. We now prepared a soluble polysaccharide marked antitumour activity, known carboxymethylpachymaran ([α]20D = −2.8°; c 1 H2O; solubility, 6.7 g/100 ml. H2O at 30° C) which labelled carboxymethyl residue 14C so its distribution cellular subcellular level investigated.
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