A Role for the CHC22 Clathrin Heavy Chain Isoform in Human Glucose Metabolism
作者： S. Vassilopoulos , C. Esk , S. Hoshino , B. H. Funke , C.-Y. Chen
关键词:
摘要: Intracellular trafficking of the glucose transporter GLUT4 from storage compartments to plasma membrane is triggered in muscle and fat during body's response insulin. Clathrin involved intracellular trafficking, humans, clathrin heavy-chain isoform CHC22 highly expressed skeletal muscle. We found a role for formation insulin-responsive human adipocytes. also associated with expanded type 2 diabetic patients. Tissue-specific introduction mice, which have only pseudogene this protein, caused aberrant localization transport pathway components their muscle, as well features diabetes. Thus, CHC22-dependent constitutes species-restricted potential implications
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P Muñoz, M Rosemblatt, X Testar, M Palacín, G Thoidis, P F Pilch, A Zorzano, The T-tubule is a cell-surface target for insulin-regulated recycling of membrane proteins in skeletal muscle. Biochemical Journal. ,vol. 312, pp. 393- 400 ,(1995) , 10.1042/BJ3120393
Jose M. Lizcano, Dario R. Alessi, The insulin signalling pathway Current Biology. ,vol. 12, ,(2002) , 10.1016/S0960-9822(02)00777-7
Yvonne Ng, Georg Ramm, Jamie A. Lopez, David E. James, Rapid Activation of Akt2 Is Sufficient to Stimulate GLUT4 Translocation in 3T3-L1 Adipocytes Cell Metabolism. ,vol. 7, pp. 348- 356 ,(2008) , 10.1016/J.CMET.2008.02.008
Brendan D. Manning, Lewis C. Cantley, AKT/PKB signaling: navigating downstream. Cell. ,vol. 129, pp. 1261- 1274 ,(2007) , 10.1016/J.CELL.2007.06.009
K. V. Kandror, P. F. Pilch, gp160, a tissue-specific marker for insulin-activated glucose transport Proceedings of the National Academy of Sciences of the United States of America. ,vol. 91, pp. 8017- 8021 ,(1994) , 10.1073/PNAS.91.17.8017
Nia J. Bryant, Roland Govers, David E. James, Regulated transport of the glucose transporter GLUT4 Nature Reviews Molecular Cell Biology. ,vol. 3, pp. 267- 277 ,(2002) , 10.1038/NRM782
C Postic, R Dentin, J Girard, Role of the liver in the control of carbohydrate and lipid homeostasis Diabetes & Metabolism. ,vol. 30, pp. 398- 408 ,(2004) , 10.1016/S1262-3636(07)70133-7
Chandrasagar B Dugani, Amira Klip, Glucose transporter 4: cycling, compartments and controversies. EMBO Reports. ,vol. 6, pp. 1137- 1142 ,(2005) , 10.1038/SJ.EMBOR.7400584
W T Garvey, L Maianu, J H Zhu, G Brechtel-Hook, P Wallace, A D Baron, Evidence for defects in the trafficking and translocation of GLUT4 glucose transporters in skeletal muscle as a cause of human insulin resistance. Journal of Clinical Investigation. ,vol. 101, pp. 2377- 2386 ,(1998) , 10.1172/JCI1557
Steven E. Kahn, Rebecca L. Hull, Kristina M. Utzschneider, Mechanisms linking obesity to insulin resistance and type 2 diabetes Nature. ,vol. 444, pp. 840- 846 ,(2006) , 10.1038/NATURE05482