Phenolic compounds from sandpaper (ficus exasperata) leaf inhibits angiotensin 1 converting enzyme in high cholesterol diet fed rats

摘要: Abstract Ethnopharmacological relevance Sandpaper [Ficus exasperata Vahl (Moraceae)] leaf has been reportedly used in folklore for the management/treatment of cardiovascular diseases with little/or no scientific basis their action. This study sought to investigate effect dietary supplementation sandpaper on angiotensin-I converting enzyme (ACE) activity hypercholesterolemia as well phenolic extract this vitro. Materials and methods The was prepared, then, inhibitory ACE determined Thereafter, high cholesterol diet fed rats 14 days evaluated some biochemical parameters. Results result revealed that under vitro condition, inhibited (IC50=14.7 µg/mL) a dose-dependent manner (0–10 µg/mL). Feeding diets caused significant (P Conclusion inhibition prevention by could be part possible mechanism underlying its anti-hypertensive property which lay credence use folk medicine. However, these activities may directly/indirectly attributed polyphenolics present.