Defective place cell activity in nociceptin receptor knockout mice with elevated NMDA receptor-dependent long-term potentiation

摘要: There is growing evidence that NMDA receptor-dependent long-term potentiation (LTP) in the hippocampus mediates synaptic plasticity underlies spatial learning and memory. LTP deficiencies correlate well with memory deficits enhancements may improve In addition, are associated abnormal place cells as expected from mapping hypothesis of hippocampal function. contrast, nothing known on how enhanced affects cells. To address this question we recorded mice lacking nociceptin receptor (NOP1/ORL1/OP4) have LTP. We found was mediated by receptors, did not require L-type calcium channels, occurred only when high frequency tetanizing stimulus trains were used. Place knockout several ways: they less stable, had noisier positional firing patterns, larger fields higher discharge rates inside outside fields. Our results suggest excessive can cause subnormal cell The effects enhancement function therefore also depend molecular details plasticity, including relationship between strength, merely magnitude strength increases. data important clinical implications development strategies to cognitive