A Selective Role for α3 Subunit Glycine Receptors in Inflammatory Pain

摘要: GlyR α3 has previously been found to play a critical role in pain hypersensitivity following spinal PGE2 injection, complete Freund’s adjuvant (CFA) and zymosan induced peripheral inflammation. In this study, although all models displayed typical phenotypic behaviours, no significant differences were observed when comparing the behaviours of Glra3-/- wild-type littermates injection capsaicin, carrageenan, kaolin/ carrageenan or monosodium iodoacetate, rheumatoid osteoarthritis, respectively. However, clear CFA (p < 0.01). No experimentally neuropathic (partial sciatic nerve ligation). Similarly, indistinguishable visceromotor responses colorectal distension (a model visceral pain) vivo cord dorsal horn electrophysiology revealed multimodal suprathreshold stimuli, intensities which equate higher scores such as those reported clinic. These data suggest that apart from its CFA- zymosan-induced sensitisation, associated with other inflammation, neuropathy disturbances involves mechanisms than EP2 receptor - pathway.