Increased dietary leucine changes the rhythm of prolactin secretion.

摘要: As we have recently shown that prolactin secretion in vitro is regulated by extracellular leucine, wanted to determine whether leucine had a similar regulatory action on the intact animal. Leucine was administered cycling female rats way of their drinking water (0.5%) for period 24 days. At daily intervals during this time, six control and leucine-treated were killed trunk blood subsequently assayed content. On days 7, 14, 21 period, pituitaries from sacrificed fixed processed electron microscopy. treatment resulted an alteration normal four-day cyclicity serum levels stimulation synthesis as evidenced ultrastructural changes pituitary mammotrophs. In parallel set experiments, vaginal smears taken nonsynchronized animals before administration. variable alterations estrus cycle depending upon stage when first administered. The disturbances persisted approximately 20 shorter experiment (seven days), alanine found no effect levels. It concluded mild elevation dietary can affect release progression cycle.