Activity of 7-methyljuglone in combination with antituberculous drugs against Mycobacterium tuberculosis.

摘要: The recent increase in the incidence of tuberculosis with emergence multidrug-resistant (MDR) cases has lead to search for new drugs that are effective against MDR strains Mycobacterium and can augment potential existing tuberculosis. In present study, we investigated activities a naphthoquinone, 7-methyljuglone, isolated from roots Euclea natalensis alone combination other antituberculous extracellular intracellular M. Combinations 7-methyljuglone isoniazid or rifampicin resulted four six-fold reduction minimum inhibitory concentration each compound. Fractional (FIC) indexes obtained were 0.2 0.5, respectively, isoniazid, suggesting synergistic interaction between these anti-TB drugs. ability enhance activity both organisms suggests may serve as promising compound development an anti-tuberculous agent.