Defects in Trophoblast Cell Lineage Account for the Impaired In Vivo Development of Cloned Embryos Generated by Somatic Nuclear Transfer
作者： Jiangwei Lin , Linyu Shi , Man Zhang , Hui Yang , Yiren Qin
DOI: 10.1016/J.STEM.2011.02.007
关键词:
摘要: The low success rate of somatic nuclear transfer (NT) is hypothesized to be mainly due functional defects in the trophoblast cell lineage rather than inner mass (ICM); this hypothesis, however, remains tested directly. Here we separated ICMs from cloned blastocysts and aggregated ICM with two fertilization-derived (FD) tetraploid (4N) embryos. We found that full-term development was dramatically improved after cells were replaced by embryos, thus providing direct evidence underlie NT.
core.ac.uk
elsevier.com
sci-hub.se 参考文章(20)
Janet Rossant, András Nagy, Elen Gócza, Elizabeth Merentes Diaz, Eszter Iványi, Merja Markkula, Valerie R. Prideaux, Embryonic stem cells alone are able to support fetal development in the mouse. Development. ,vol. 110, pp. 815- 821 ,(1990) , 10.1242/DEV.110.3.815
S.C. Barton, M.A. Surani, Y. Tsunoda, K. Hilton, W.M. Rideout, Y. Kato, Developmental potential of mouse primordial germ cells Development. ,vol. 126, pp. 1823- 1832 ,(1999) , 10.1242/DEV.126.9.1823
Jinsong Li, Tomohiro Ishii, Duancheng Wen, Peter Mombaerts, Non-equivalence of cloned and clonal mice Current Biology. ,vol. 15, pp. R756- R757 ,(2005) , 10.1016/J.CUB.2005.09.010
D. Humpherys, Epigenetic Instability in ES Cells and Cloned Mice Science. ,vol. 293, pp. 95- 97 ,(2001) , 10.1126/SCIENCE.1061402
Guy S. Eakin, Richard R. Behringer, Tetraploid development in the mouse. Developmental Dynamics. ,vol. 228, pp. 751- 766 ,(2003) , 10.1002/DVDY.10363
H. Miki, N. Wakisaka, K. Inoue, N. Ogonuki, M. Mori, J.-M. Kim, A. Ohta, A. Ogura, Embryonic rather than extraembryonic tissues have more impact on the development of placental hyperplasia in cloned mice. Placenta. ,vol. 30, pp. 543- 546 ,(2009) , 10.1016/J.PLACENTA.2009.03.006
Hiroshi Ohta, Yuko Sakaide, Kazuo Yamagata, Teruhiko Wakayama, Increasing the Cell Number of Host Tetraploid Embryos Can Improve the Production of Mice Derived from Embryonic Stem Cells Biology of Reproduction. ,vol. 79, pp. 486- 492 ,(2008) , 10.1095/BIOLREPROD.107.067116
Yuka Okada, Yuko Ueshin, Ayako Isotani, Tomoko Saito-Fujita, Hisako Nakashima, Kazushi Kimura, Akira Mizoguchi, Masatsugu Oh-hora, Yoshiko Mori, Masato Ogata, Robert G Oshima, Masaru Okabe, Masahito Ikawa, Complementation of placental defects and embryonic lethality by trophoblast-specific lentiviral gene transfer Nature Biotechnology. ,vol. 25, pp. 233- 237 ,(2007) , 10.1038/NBT1280
Maite Rielland, Vincent Brochard, Marie-Christine Lacroix, Jean-Paul Renard, Alice Jouneau, Early alteration of the self-renewal/differentiation threshold in trophoblast stem cells derived from mouse embryos after nuclear transfer Developmental Biology. ,vol. 334, pp. 325- 334 ,(2009) , 10.1016/J.YDBIO.2009.07.022
A. Jouneau, Developmental abnormalities of NT mouse embryos appear early after implantation Development. ,vol. 133, pp. 1597- 1607 ,(2006) , 10.1242/DEV.02317