BRAIN-DERIVED NEUROTROPHIC FACTOR INHIBITS OSMOTIC SWELLING OF RAT RETINAL GLIAL (MULLER) AND BIPOLAR CELLS BY ACTIVATION OF BASIC FIBROBLAST GROWTH FACTOR SIGNALING
作者： B.-A. Berk , S. Vogler , T. Pannicke , H. Kuhrt , T.B. Garcia
DOI: 10.1016/J.NEUROSCIENCE.2015.03.037
关键词:
摘要: Water accumulation in retinal glial (Muller) and neuronal cells resulting cellular swelling contributes to the development of edema neurodegeneration. Intravitreal administration neurotrophins such as brain-derived neurotrophic factor (BDNF) is known promote survival neurons. Here, we show that exogenous BDNF inhibits osmotic Muller cell somata induced by superfusion rat slices or freshly isolated with a hypoosmotic solution containing barium ions. also inhibited bipolar slices, but failed inhibit soma cells. The inhibitory effect on was mediated activation tropomyosin-related kinase B (TrkB) transactivation fibroblast growth receptors. Exogenous basic (bFGF) fully while it partially somata. Isolated displayed immunoreactivity truncated TrkB, not full-length TrkB. rod immunoreactivities both TrkB isoforms. Data suggest neuroprotective retina part prevention cytotoxic While directly acts indirectly inducing release factors like bFGF swelling.
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